Semilobar Holoprosencephaly with Neurogenic Hypernatraemia : Two new cases
Holoprosencephaly (HPE) is a Kits developmental defect of the embryonic forebrain and midface.It is due to the non-cleavage of the embryonic forebrain into two cerebral hemispheres and the incomplete development of the paramedian structures.The overall prevalence is 1.31 per 10,000 births.The aetiology could be genetic,environmental, or both.HPE is